主要研究兴趣：

1）无菌性炎症中的固有免疫识别和活化机制；

2）无菌性炎症中的神经和代谢调控机制;

3）靶向无菌性炎症的药物发现

教授,  博士生导师,  入选“国家级人才项目”，基金委创新群体、杰青和科技部重点研发计划项目负责人。主要从事无菌性炎症中的固有免疫识别、调控及疾病干预研究，以通讯作者在Science、Cell、Nat Rev Immunol、Nat Immunol、Immunity、Nat Cell Biol等杂志发表论文20余篇，他引13000余次。获国家自然科学二等奖（第一完成人）、谈家桢生命科学创新奖、中国优秀青年科技人才奖、中国青年科技奖、树兰医学青年奖、药明康德生命化学奖等奖项。担任Cellular & Molecular Immunology编委。任中国免疫学会常务理事、青年工作委员会主任委员，基础免疫分会副主任委员、安徽省免疫学会副理事长。

承担科研任务：

科技部重点研发项目、基金委创新群体项目、基金委杰出青年基金项目、基金委重大研究计划项目、中科院先导项目等

代表性学术论文：

1. Xu Y, Yan J, Tao Y, Qian X, Zhang C, Yin L, Gu P, Liu Y, Pan Y, Tang R, Jiang W, Zhou R. Pituitary hormone α-MSH promotes tumor-induced myelopoiesis and immunosuppression. Science. 2022 Sep 2;377(6610):1085-1091. doi: 10.1126/science.abj267

2. Wang X, Cai J, Lin B, Ma M, Tao Y, Zhou Y, Bai L, Jiang W, Zhou R. GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair. Immunity.2021 Jun 8;54(6):1123-1136.e8

3.  Huang Y, Wang H, Hao Y, Lin H, Dong M, Ye J, Song L, Wang Y, Li Q, Shan B, Jiang Y, Li H, Shao Z, Kroemer G, Zhang H, Bai L, Jin T, Wang C, Ma Y, Cai Y, Ding C, Liu S, Pan Y, Jiang W, Zhou R. Myeloid PTEN promotes chemotherapy-induced NLRP3 inflammasome activation and antitumor immunity. Nat Cell Biol. 2020 Jun;22(6):716-727.

4. Gong T, Liu L, Jiang W, Zhou R. DAMP-sensing receptors in sterile inflammation and inflammatory diseases. Nat Rev Immunol. 2020 Feb;20(2):95-112. 

5. Liu L, Gong T, Tao W, Lin B, Li C, Zheng X, Zhu S, Jiang W, Zhou R. Commensal viruses maintain intestinal intraepithelial lymphocytes via noncanonical RIG-I signaling. Nat Immunol. 2019 Dec;20(12):1681-1691

6.  Gong T, Zhou R. ApoC3: an 'alarmin' triggering sterile inflammation. Nat Immunol. 2020 Jan;21(1):9-11.

7.  Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z, Zhou R. Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome. Cell. 2015 Jan 15;160(1-2):62-73. 

8.  Wang X, Jiang W, Yan Y, Gong T, Han J, Tian Z, Zhou R. RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway. Nat Immunol. 2014 ;15(12):1126-33.

9.  Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C, Guarda G, Tian Z, Tschopp J, Zhou R. ω-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity. 2013 Jun 27;38(6):1154-63. 

10. Jiang H, He H, Chen Y, Huang W, Cheng J, Ye J, Wang A, Tao J, Wang C, Liu Q, Jin T, Jiang W, Deng X, Zhou R. Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J Exp Med 2017 Nov 6;214(11):3219-3238.

联系方式：

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传真: 0551-63600831  

邮箱: [email protected]